Examples of Pooling for COVID-19
Generally there are 3 kinds of reports on pooling for COVID-19:
- General Report: These reports show that one or more positive samples can be pooled together and still recover a positive result. These papers are useful for establishing the limits of how large a pool can be (at least in the hands of that group), but don't actually carry out extenstive screening on patient samples.
- Dorfman Screening These reports describe a Dorfman type, two stage screening protocol. In this protocol, samples are first pooled (ideally based on the prevalence of positive samples in the population). Pools that come back positive are then re-tested individually in a second round of testing. These kinds of screens are fairly common.
- Combinatoric Screening These reports describe an Origami Assay type one stage screening protocol. In this protocol, samples are pooled in a structured way, and then all pools are tested. The combined pooling data then can be decoded to identify positive samples. These protocols are less common.
Below I divide reports into these three categories: